Sustained release nanosuspension of acetaminophen- formulation and in-vitro evaluation

  • Ajay J.Y Department of Pharmaceutical Technology, SCBT, SASTRA University, Thanjavur – 613 401, Tamil Nadu, India
  • Pradeep kumar Gajula Department of Pharmaceutical Technology, SCBT, SASTRA University, Thanjavur – 613 401, Tamil Nadu, India
  • Vedha Hari B.N Department of Pharmacy, SCBT, SASTRA University, Thanjavur – 613 401, Tamil Nadu, India

Abstract

The aim of this study was to prepare and characterize nanosuspensions of poorly water soluble drug (Acetaminophen) by modified solvent diffusion method using Eudragit L-100 polymer in order to sustain the release of Acetaminophen. Nanosuspension was subjected to various studies like particle size, pH, drug content, density, drug- polymer interaction, in-vitro drug release and release kinetics. The spectral analysis revealed that there was no interaction and presence of drug. In-vitro studies showed sustained release of the drug for prolonged period.

Keywords: Paracetamol, Nanotechnology, Methylmethacrylate

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Published
2012-01-25
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How to Cite
Ajay J.Y, Pradeep kumar Gajula, & Vedha Hari B.N. (2012). Sustained release nanosuspension of acetaminophen- formulation and in-vitro evaluation. International Journal of Research in Pharmaceutical Sciences, 3(1), 67-71. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/998
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Original Articles
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