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Rheumatoid arthritis (RA) and Sjogren’s syndrome (SS) receives more attention among all other autoimmune disorders. Because the patients those who have affected by RA are more susceptible to SS and vice versa. The principle behind this the common agent rheumatoid factor (RF) is involved in both diseases. In addition to this SSA/anti-Ro and SSB/anti-La are mostly involved in Sjogren’s syndrome. These proteins also share some of the common similarities with RA. The purpose of this study was to comparatively analyze the common interaction network of proteins, such as, RF (involved in both RA and Sjogren’s syndrome), SSA/anti-Ro, and SSB/anti-La. This study uses in silico methods in order to improve the understanding of the complex interactions that occur between molecules related to RA and Sjogren’s syndrome. The interacted proteins and their domains and sequence positions are displayed with the respective confidence score and homology percentage. The present study reported that the protein-protein interactions have been occurred mostly between the Ig light chain and heavy chain variable regions of RF (both RA and SS) and SSA/anti-Ro. Another kind of interactions has also been found between HLA, CALR, and TAP2 of SSA/anti-Ro and SSB/Anti-La. The clinical manifestations of RA and Sjogrens syndrome were found most frequently in patients with RF, anti-SS-B/La and/or -SS-A/Ro antibodies, when the particular domains and sequence positions of the antibodies are uniquely present in them.
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