Formulation and Optimisation of Osmotic pump of Propranolol Hydrochloride using EOP and Microporous concepts

  • Ghedia Tejaskumar P Department of Pharmaceutics, Sigma Institute of Pharmacy, Bakrol village, Ajwa-Nimeta Road, Baroda, Gujarat, India
  • Patel Parth Department of Pharmaceutics, Sigma Institute of Pharmacy, Bakrol village, Ajwa-Nimeta Road, Baroda, Gujarat, India
  • Christian Vishal Department of Pharmaceutics, Sigma Institute of Pharmacy, Bakrol village, Ajwa-Nimeta Road, Baroda, Gujarat, India
  • Panchal Amish Department of Pharmaceutics, Sigma Institute of Pharmacy, Bakrol village, Ajwa-Nimeta Road, Baroda, Gujarat, India
  • Bamaniya Sanjay Department of Pharmaceutics, Sigma Institute of Pharmacy, Bakrol village, Ajwa-Nimeta Road, Baroda, Gujarat, India
  • Sangada Kiran Department of Pharmaceutics, Sigma Institute of Pharmacy, Bakrol village, Ajwa-Nimeta Road, Baroda, Gujarat, India

Abstract

Propranolol Hydrochloride is class I drug and hence completely and rapidly absorbed which shows quick but shorter action which leads to frequent dosing. This fact gives opportunity to develop controlled release formulation. The controlled release tablet of Propranolol hydrochloride was prepared based on osmotic pump technique. Core tablet of Propranolol hydrochloride was prepared using Sodium chloride, Mannitol, PVP K30, MCC, talc & Mg. stearate; and the tablets of selected batch was coated with coating solution containing different proportions of Cellulose acetate, Castor oil and PEG400 and evaluated for in vitro drug release studies. The comparison study of the formulations has shown that all batches showing sustained release profile following zero order and batch F3 showing the maximum correlation with zero order release and hence considered as optimized batch. The observed result revels that osmotic agents have significant effect on drug release up to 12h. in successful development of dual release osmotic pump tablets containing Propranolol Hydrochloride by using Sodium chloride and Mannitol as key excipients.

Keywords: Controlled release tablet, Elementary Osmotic Pump, Mannitol, micro porous osmotic pump, Poly ethylene glycol 400, Propranolol hydrochloride, sodium chloride

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Published
2011-10-20
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How to Cite
Ghedia Tejaskumar P, Patel Parth, Christian Vishal, Panchal Amish, Bamaniya Sanjay, & Sangada Kiran. (2011). Formulation and Optimisation of Osmotic pump of Propranolol Hydrochloride using EOP and Microporous concepts. International Journal of Research in Pharmaceutical Sciences, 2(4), 590-595. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/969
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Original Articles
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