Formulation and Optimisation of Osmotic pump of Propranolol Hydrochloride using EOP and Microporous concepts
Propranolol Hydrochloride is class I drug and hence completely and rapidly absorbed which shows quick but shorter action which leads to frequent dosing. This fact gives opportunity to develop controlled release formulation. The controlled release tablet of Propranolol hydrochloride was prepared based on osmotic pump technique. Core tablet of Propranolol hydrochloride was prepared using Sodium chloride, Mannitol, PVP K30, MCC, talc & Mg. stearate; and the tablets of selected batch was coated with coating solution containing different proportions of Cellulose acetate, Castor oil and PEG400 and evaluated for in vitro drug release studies. The comparison study of the formulations has shown that all batches showing sustained release profile following zero order and batch F3 showing the maximum correlation with zero order release and hence considered as optimized batch. The observed result revels that osmotic agents have significant effect on drug release up to 12h. in successful development of dual release osmotic pump tablets containing Propranolol Hydrochloride by using Sodium chloride and Mannitol as key excipients.
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