Effect and evaluation of antihyperlipidemic activity of fractions of total meth-anol extract of Bauhinia variegata (Linn.) leaves on Triton WR-1339 (Tylox-apol) induced hyperlipidemic rats

  • Deepak Kumar Department of Pharmaceutical Chemistry, Dolphin PG Institute of Biomedical and Natural Sciences, Manduwala, Dehradun, Uttarakhand, India
  • Versha Parcha Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, 248161, India
  • Alok Maithani Department of Pharmaceutical Chemistry, GRD (PG) Institute of Management and Technology, Rajpur, Dehradun, India
  • Ishan Dhulia Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Balawala, Dehradun, 248161, India

Abstract

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. The present study focus on the anti-hyperlipidemic activity of fractions of total methanol extract of leaves of Bauhinia variegata (Linn.) against Triton WR-1339 induced hyperlipidemia in rats. Fractions administered a dose of 100mg/kg (oral) to the Triton WR-1339 induced hyperlipidemic rats. Butanol fraction showed significant reduction (p<0.05) in serum cholesterol (78.86 mg/dl), triglyceride (113.52 mg/dl), LDL (28.01 mg/dl), VLDL (20.70 mg/dl) and increase in HDL level (30.15 mg/dl) in comparison with standard drug fenofibrate (p<0.05).

Keywords: Bauhinia variegata (Linn.), Triton WR-1339, Anti-hyperlipidemic, Tyloxapol, Atherosclerosis, fenofibrate

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Published
2011-10-20
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How to Cite
Deepak Kumar, Versha Parcha, Alok Maithani, & Ishan Dhulia. (2011). Effect and evaluation of antihyperlipidemic activity of fractions of total meth-anol extract of Bauhinia variegata (Linn.) leaves on Triton WR-1339 (Tylox-apol) induced hyperlipidemic rats. International Journal of Research in Pharmaceutical Sciences, 2(4), 493-497. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/932
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Original Articles
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