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Abstract

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. The present study focus on the anti-hyperlipidemic activity of fractions of total methanol extract of leaves of Salvadora oleoides (Decne.) against Triton WR-1339 induced hyperlipidemia in rats. Fractions administered a dose of 100mg/kg (oral) to the Triton WR-1339 induced hyperlipidemic rats. Butanol fraction showed significant reduction (p<0.05) in serum cholesterol (61.73 mg/dl), triglyceride (121.25 mg/dl), LDL (37.89 mg/dl), VLDL (24.98 mg/dl) and increase in HDL level (36.44 mg/dl) in comparison with standard drug fenofibrate (p<0.05).

Keywords

Salvadora oleoides (Decne.) Triton WR-1339 Anti-hyperlipidemic Tyloxapol Atherosclerosis fenofibrate

Article Details

How to Cite
Deepak Kumar, Versha Parcha, Ishan Dhulia, & Alok Maithani. (2011). Effect and evaluation of antihyperlipidemic activity of fractions of total meth-anol extract of Salvadora oleoides (decne.) leaves on Triton WR-1339 (Tylox-apol) induced hyperlipidemic rats. International Journal of Research in Pharmaceutical Sciences, 2(3), 507-510. Retrieved from https://pharmascope.org/ijrps/article/view/922