Screening of antioxidant activity of Mucuna pruriens by in vivo model

  • Rakam Gopi Krishna Department of Pharmaceutical chemistry, Chaitanya College of Pharmacy Education and Research, Kishanpura, Hanamkonda, Warangal -506001, Telangana, India
  • Raja Sundararajan GITAM Institute of Pharmacy, GITAM (Deemed to be University, Visakhapatnam- 530 045, Andhra Pradesh, India

Abstract

The present study was anticipated for reviewing the in vivo antioxidant influence of methanolic extract of Mucuna pruriens. Methanolic extract of the plant was given to rats separately at dissimilar binary amounts of 250 and 500 mg/kg for 21 days to estimate oxidative stress factors such as thiobarbituric acid reactive substance, ferric reducing ability of plasma & reduced glutathione and to evaluate antioxidant enzyme levels of catalase & superoxide dismutase. The Mucuna pruriens extracts of methanol deliberately (p<0.05) raised the ferric reducing ability of plasma on seven, fourteen and twenty-one days of treatment. Significant (p<0.05) decrease of thiobarbituric acid reactive substance levels beside with an upturn in the superoxide dismutase level in the liver and kidney at two dissimilar doses of the plant was witnessed. Management with a dose of 500 mg/kg b.wt of Mucuna pruriens produced a significant progression in catalase levels. However, there was no major effect of thiobarbituric acid reactive substance, superoxide dismutase & catalase in the heart and reduced glutathione level at two different doses of Mucuna pruriens was noticed. These outcomes recommend that the leaves of Mucuna pruriens have potent antioxidant activity which may be responsible for some of its reported pharmacological actions.

Keywords: Mucuna pruriens, Antioxidant activity, FRAP, Catalase, TBARS, GSH

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Published
2019-01-05
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How to Cite
Rakam Gopi Krishna, & Raja Sundararajan. (2019). Screening of antioxidant activity of Mucuna pruriens by in vivo model. International Journal of Research in Pharmaceutical Sciences, 10(1), 523-530. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/92
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Original Articles
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