Evaluation of thrombolytic properties of Nigella sativa, Capsicum frutescens and Brassica oleracea

  • Md. Arifuzzaman Department of Biochemistry & Biotechnology, University of Science & Technology Chittagong (USTC), Chit-tagong, Bangladesh
  • Adnan Mannan Department of Genetic Engineering & Biotechnology, University of Chittagong, Chittagong, Bangladesh
  • Imtha Sal Binta Abdullah Department of Biochemistry & Biotechnology, University of Science & Technology Chittagong (USTC), Chit-tagong, Bangladesh
  • Jesmin Abedin Department of Biochemistry & Biotechnology, University of Science & Technology Chittagong (USTC), Chit-tagong, Bangladesh
  • Md. Sheikh Anwar Department of Pharmacy, University of Science & Technology Chittagong (USTC), Chittagong, Bangladesh ⁴Department of Pharmacy, BGC Trust University, Chittagong, Bangladesh
  • S.M. Zahid Hosen Department of Pharmacy, BGC Trust University, Chittagong, Bangladesh
  • Sabuj Barua Department of Pharmacy, BGC Trust University, Chittagong, Bangladesh

Abstract

Thrombolytic drugs are widely used for the management of cerebral venous sinus thrombosis patients. Several in vitro models have been developed to study clot lysis activity of thrombolytic drugs, but all of these have certain limitations. The present study was carried out to investigate the thrombolytic activity, synergistic activity on thrombolysis in the aqueous extract of fruits of Nigella sativa, Capsicum frutescens, Brassica oleracea. An in vitro thrombolytic method was used to investigate the thrombolytic activity of plant extracts in blood sample from healthy human volunteers, along with streptokinase as a positive control and water as a negative control. Same method was also applied to assess the synergistic activity of plant extracts with streptokinase. Aqueous extract of Nigella sativa, Capsicum frutescens, Brassica oleracea showed 40.65%, 36.93%, 57.03% thrombolytic activity and also showed 60.46%, 80.00%, 72.50% synergistic activity with streptokinase respectively. Among the plant extracts studied Capsicum frutescens showed significant % of synergistic activity (80%) with compared to other plant extracts. The present study demonstrates that Capsicum frutescens extract showed synergistic activity with streptokinase on thrombolysis. Isolation and purification of the compound responsible for synergistic activity would be one of the best sources of herbal drugs for atherothrombotic diseases.

Keywords: Clot lysis, Herbal preparation, Streptokinase, Synergistic effect, Atherothrombotic disease

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Published
2011-07-20
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How to Cite
Md. Arifuzzaman, Adnan Mannan, Imtha Sal Binta Abdullah, Jesmin Abedin, Md. Sheikh Anwar, S.M. Zahid Hosen, & Sabuj Barua. (2011). Evaluation of thrombolytic properties of Nigella sativa, Capsicum frutescens and Brassica oleracea. International Journal of Research in Pharmaceutical Sciences, 2(3), 483-487. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/913
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Original Articles
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