Synthesis, characterization and antifungal activity of quinazoline -4-one deriv-atives containing 8-hydroxy quinazoline ligand and its transition metal che-lates

  • R. T. Vashi Department of Chemistry, Navyug Science College, Rander Road, Surat - 395 009 India
  • C. D. Shelat Department of Chemistry, Navyug Science College, Rander Road, Surat - 395 009 India
  • Himanshu Patel Department of Chemistry, Navyug Science College, Rander Road, Surat - 395 009 India

Abstract

The novel ligand HL3 was synthesized using 2-Chloromethyl-3-(8-hydroxyquinolin-5-yl)-3(H)- quinozolin-4-one and it was undergo the chelating reaction with Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) to prepare transition metal chelates. These chelates were characterized by physicochemical methods such as elemental analysis, conductometric studies, magnetic susceptibility, FT-IR, NMR and electronic spectral data. The stoichiometry of the complex has been found to be 1: 2 (Metal: ligand). An octahedral geometry around Co(II), Ni(II) and Mn(II), distorted octahedral geometry around Cu(II) and tetra hedral geometry around Zn(II) have been proposed. The antifungal activity of ligand and its metal chelates was conducted against various fungi.

Keywords: Ligand, 8-hydroxyquinoline, IR and NMR spectral studies, magnetic moment, antifungal study

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Published
2011-07-20
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How to Cite
R. T. Vashi, C. D. Shelat, & Himanshu Patel. (2011). Synthesis, characterization and antifungal activity of quinazoline -4-one deriv-atives containing 8-hydroxy quinazoline ligand and its transition metal che-lates. International Journal of Research in Pharmaceutical Sciences, 2(3), 399-403. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/892
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