Preparation and characterization of Cefadroxil loaded alginate microbeads

  • Sowjanya Battu Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampeta - 516 126, Ka-dapa Dist., Andhra Pradesh, India
  • R. Indira Prasanna Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampeta - 516 126, Ka-dapa Dist., Andhra Pradesh, India
  • K. Jyothshna Devi Department of pharmaceutics, Sri Venkateshwara University, Tirupathi, Chitoor Dist., Andhra Pradesh, India
  • Narayana Swamy Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampeta - 516 126, Kadapa Dist., Andhra Pradesh, India
  • C. Madhusudhana Chetty Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampeta - 516 126, Kadapa Dist., Andhra Pradesh, India
  • M. Purushothaman Department of Pharmaceutics, Vasavi College of Pharmacy, Bakrapeta - 516 126, Kadapa Dist., Andhra Pradesh, India
  • K. Gnanaprakash Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampeta - 516 126, Kadapa Dist., Andhra Pradesh, India

Abstract

Cefadroxil is a broad spectrum antibiotic that acts against an extensive variety of bacteria, including Gram-positive and Gram-negative bacteria. The major drawback of orally administered drug like cefadroxil is its shorter half life of 1.2 hrs. The goal of the study is to prolong the drug release, producing a desired blood serum level, reduction in drug toxicity and improving the patient compliance by prolonging the dosing intervals. The present research highlights the formulation and evaluation of cefadroxil loaded microbeads using polymers such as carbopol and sodium carboxy methyl cellulose while sodium alginate being the common polymer with a cross linking agent being calcium chloride. The beads were prepared by “Ionotropic gelation technique” and characterized for its particle size shape, micromeritic properties, percentage drug loading, percentage drug entrapment efficiency, swelling ratio and In vitro drug release studies. The release studies were obtained up to 12 hrs from 3 batches. The in vitro release data were fit to different equations and kinetic models to explain release profiles. The kinetic models used were zero order, Higuchi’s and Peppa’s. The correlation coefficient value (r) indicates the kinetic of drug release was zero order and the mechanism of drug release was found to be super case II transport.

Keywords: Cefadroxil, Ionotropic gelation technique, Carbopol 934, Sodium alginate, Sodium carboxy methyl cellulose

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Published
2010-10-22
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How to Cite
Sowjanya Battu, R. Indira Prasanna, K. Jyothshna Devi, Narayana Swamy, C. Madhusudhana Chetty, M. Purushothaman, & K. Gnanaprakash. (2010). Preparation and characterization of Cefadroxil loaded alginate microbeads. International Journal of Research in Pharmaceutical Sciences, 1(4), 386-390. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/890
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