Short term antidiabetic studies on alcoholic root extract of Pseudarthria vis-cida Linn.

  • K. Rajendran Department of Pharmacognosy, College of Pharmacy, Al-Jabal Al-Gharbi University, Al-Zawia, Libya
  • Kishore Gana Sam Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal 576 104, India
  • K.K. Srinivasan Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal 576 104, India
  • Annie Shirwaikar Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576 104, India

Abstract

Pseudarthria viscida (L.) Wight and Arnott. (Leguminosae) commonly known as Salaparani and its roots are commonly used by the tribes of Madhya Pradesh. A short study was undertaken as a preliminary investigation to evaluate the antidiabetic effect of the alcoholic root extract by oral glucose tolerance test (OGTT), normoglycemic and antihyperglycemic activity in streptozotocin (STZ)-nicotinamide induced non insulin-dependent diabetes mellitus rats. Graded doses (250 and 500 mg/kg) of the alcoholic root extract suspended in gum acacia were administered to normal and experimental diabetic rats. Effect on glucose tolerance test showed a significant fall in the blood glucose level of extract treated animals after 1 hr, indicating its hypoglycemic activity. Continuous blood glucose lowering activity was observed till 4 hr of administration in normoglycemic and diabetic rats. The results were compared with standard drug glibenclamide.

Keywords: Pseudarthria viscida, Root, Antidiabetic activity, Streptozotocin, Nicotinamide, Rats

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Published
2010-07-25
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How to Cite
K. Rajendran, Kishore Gana Sam, K.K. Srinivasan, & Annie Shirwaikar. (2010). Short term antidiabetic studies on alcoholic root extract of Pseudarthria vis-cida Linn. International Journal of Research in Pharmaceutical Sciences, 1(3), 382-385. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/872
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Original Articles
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