Main Article Content

Abstract

A simple, reproducible and efficient spectroscopic method development and validation of hydrochlorothiazide in tablet dosage form. The drug was ermined by using methanol as a solvent for this study, which is determined by spectrophotometrically at 224-nm.the percentage recovery study of the drug for the proposed method range from 99-100%w/v indicating no interferences of the tablet excipients, by using methanol as a solvent. Linearity was obtained in the concentration range 10-50 µg/ml for the hydrochlorothiazide with correlation coefficient of 0.9916. The result analysis was validated statistically and recovery studies confirmed the accuracy and precision of the proposed method.

Keywords

Hydrochlorothiazide Methanol UV spectrophotometer

Article Details

How to Cite
Alagar Raja M, & Selvakumar D. (2010). Method development and validation of hydrochlorothiazide in tablet dosage form by UV spectroscopy. International Journal of Research in Pharmaceutical Sciences, 1(3), 369-371. Retrieved from https://pharmascope.org/ijrps/article/view/870