Synthesis and antimicrobial activity of some 2-[(2- substituted-phenyl-5-methyl-1, 3-thiazolidin-4-one)-5-(2'-methylamino-4-phenyl-1', 3'- thiazolyl]-1, 3, 4-thiadiazoles

  • Rajiv Dua Synthetic Organic Medicinal Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour Central University, Sagar, Madhya Pradesh - 470003 India
  • S.K. Sonwane Synthetic Organic Medicinal Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour Central University, Sagar, Madhya Pradesh - 470003 India
  • S.D. Srivastava Synthetic Organic Medicinal Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour Central University, Sagar, Madhya Pradesh - 470003 India
  • S.K. Srivastava Synthetic Organic Medicinal Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour Central University, Sagar, Madhya Pradesh - 470003 India

Abstract

A new 2-[(2-substituted phenyl-5-methyl-1,3-thiazolidin-4-one)-5-(2'-methylamino-4-phenyl-1',3'-thiazolyl]-1,3,4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methyl-amino 4'-phenyl-1',3'-thiazolyl]-1,3,4-thiadiazole, 4(a-n) using 2-amino-4-phenyl-1,3-thiazole as a starting material. The synthesised compounds have been screened in vitro for their antimicrobial activity against Bacillus subtilis, Escherichia coli. Klebsiella pneumoniae and Streptococcus aureus bacteria and Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride fungi respectively. Some of the compounds displayed pronounced biological activity.

Keywords: 2-Amino-4-phenyl-1,3-thiazole, Thiadiazole, Arylidene, 4-Thiazolidinone, Antimicrobial activity

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Published
2010-07-25
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How to Cite
Rajiv Dua, S.K. Sonwane, S.D. Srivastava, & S.K. Srivastava. (2010). Synthesis and antimicrobial activity of some 2-[(2- substituted-phenyl-5-methyl-1, 3-thiazolidin-4-one)-5-(2’-methylamino-4-phenyl-1’, 3’- thiazolyl]-1, 3, 4-thiadiazoles. International Journal of Research in Pharmaceutical Sciences, 1(3), 358-364. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/868
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Original Articles
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