Synthesis and anti-convulsant screening of novel Schiff bases of 3-amino-2-methyl quinazolin-4-(3H)-one

  • Govindaraj Saravanan Medicinal chemistry research laboratory, Bapatla College of Pharmacy, Bapatla-522 101, Andra Pradesh, India
  • Perumal Pannerselvam Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Jyothi Nagar, Thorapakkam, Chen-nai-600 096, Tamil Nadu, India
  • Chinnasamy Rajaram prakash Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Jyothi Nagar, Thorapakkam, Chen-nai-600 096, Tamil Nadu, India

Abstract

In the present study, a novel schiff bases were synthesized by condensation of 3-amino-2-methyl quinazolin-4-(3H)-ones with different aromatic aldehyde. The 3-amino-2-methyl quinazolin-4-(3H)-one was synthesized from anthranilic acid via 2-methyl benzoxazin-4-one. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, 13C-NMR, mass spectral and elemental analysis. These compounds were screened for anti-convulsant activity by MES method in mice. All the compounds exhibited significant anti-convulsant activity. Entire title compounds exhibit more effect on extensor phase than flexion phase. 3-(4-methyl benzylideneamino)-2-methyl quinazolin-4(3H)-one (4f) exhibited highest activity among the series. Compound 4d and 4e exhibited moderate activity.

Keywords: 3-Amino-2-methyl quinazolin-4-(3H)-one, Schiff base, anti-convulsant

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Published
2010-07-25
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How to Cite
Govindaraj Saravanan, Perumal Pannerselvam, & Chinnasamy Rajaram prakash. (2010). Synthesis and anti-convulsant screening of novel Schiff bases of 3-amino-2-methyl quinazolin-4-(3H)-one. International Journal of Research in Pharmaceutical Sciences, 1(3), 277-281. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/842
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