Pharmacokinetics of amoxicillin loaded sepia Nanoparticles in healthy rabbits

  • S. Ramesh Sri Padmavathi School of Pharmacy, Thiruchanoor, Tirupathi, Andhra Pradesh, India
  • D. Ranganayakulu Sri Padmavathi School of Pharmacy, Thiruchanoor, Tirupathi, Andhra Pradesh, India
  • P. Ravikiran Sri Padmavathi School of Pharmacy, Thiruchanoor, Tirupathi, Andhra Pradesh, India
  • C. Madhusudhana Chetty Annamacharya college of Pharmacy, New boyanapalli, Rajampeta, Kadapa, Andhra Pradesh, India
  • A. Sathya Sri Padmavathi School of Pharmacy, Thiruchanoor, Tirupathi, Andhra Pradesh, India

Abstract

The main aim of the present study was to evaluate the Pharmacokinetic profiles amoxicillin nanoparticles after oral administrations in rabbits. The sepia nanoparticles were prepared by using the controlled gellification process. In this research work different drug and polymer ratios were used. The prepared sepia nanoparticles were used for the determination of pharmacokinetics parameters such as Cmax , Tmax, AUC, absorption rate constant, Elimination rate constant and biological half life. The, pharmacokinetics parameters results were obtained viz. Cmax (8.6 µg/ ml), Tmax (39.25 hrs), AUC (130.58 µg / ml /hr), absorption rate constant (0.0069), Elimination rate constant (0.634) and biological half life (10.43 hrs). So by observing of all the pharmacokinetic parameters, we concluded that the prepared nanoparticles having the good pharmacokinetic profile

Keywords: Pharmacokinetic parameters, absorption rate constant, amoxicillin, sepia nanoparticles, gellification method.

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Published
2010-07-25
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How to Cite
S. Ramesh, D. Ranganayakulu, P. Ravikiran, C. Madhusudhana Chetty, & A. Sathya. (2010). Pharmacokinetics of amoxicillin loaded sepia Nanoparticles in healthy rabbits. International Journal of Research in Pharmaceutical Sciences, 1(3), 229-231. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/786
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