Physicochemical characterization of atenolol mucoadhesive tablet
The buccal mucosa has confirmed principally valuable and provides more advantages than other dosage forms such as bypass of the GIT, improving the bioavailability of therapeutic agent that has high first-pass metabolism, controlled drug delivery, ease of application and immediate withdrawal of delivery by detaching the system. The aim of the study was to formulate and evaluate mucoadhesive atenolol buccal tablets for systemic delivery. Atenolol tablets were prepared by direct compression using ethyl cellulose and mucoadhesive polymers namely, Sodium alginate, Hydroxyl propyl cellulose and Methylcellulose. All the formulations were subjected to physicochemical evaluation such as hardness, thickness, friability, surface pH, swelling index and weight variation. The mean surface pH and ex-vivo residence time of the prepared tablets were found to 6.8-7.10 and 6.6±0.92 to 7.00±0.01 which is favorable for oral mucosa. In-vitro drug release studies demonstrated that atenolol release from the selected tablets followed diffusion kinetics with a maximum drug release and it is confirmed that the tablet has the ability to deliver the drug. The present study indicates atenolol buccal tablet for systemic delivery with an added advantage of circumventing the hepatic first-pass metabolism.
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