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The aim of this study was to determine the status of hypothyroidism in a group of patients with b-thalassemia major & to know the correlation between thyroid function and the degree of iron overload represented by S. ferritin level .The cross-sectional study did 100 cases of b-thalassemia major, 50 patient >10 years of age and 50 patient between 5-10 years of age by using the principle of measuring T3, T4, TSH, and serum ferritin combines an enzyme immunoassay competition with a final fluorescent method (ELFA).A total number of patient 100, 50 patient >10yr. of age 5 cases (10%) with elevated TSH 5-10µIU/ml & normal T4 who diagnosed as subclinical hypothyroidism and 2cases (4%) with elevated TSH & low T4 who diagnosed as overt hypothyroidism. While another group 50 patient [age < 10 years] of them only there are 4 cases (8%) of subclinical hypothyroidism. Patients with lack of clinical symptoms of hypothyroidism sometimes involved subclinical cases. Standard follow-up for early recognition and appropriate, managements of this complication might make the patient’s life better.
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