Main Article Content
Itraconazole, an Anti-fungal drug, which is poorly soluble in water. It requires Enhancement in dissolution rate for enhancing its oral bioavailability by several techniques. The prepared Itraconazole tablets possess good physicochemical characteristics and the in vitro dissolution and release rate kinetics were originated acceptable. Deviations were found in dissolution rate, efficiency for the Itraconazole tablets. The factors viz., used of Poly ethylene glycol 6000, Poly Vinyl Pyrrolidone and Dicalcium Phosphate, as A, B and C respectively and the combined factors also observed. Formulations F3 and F7 gave good dissolution rate and efficiency values. Addition of PVP 2% resulted in increased dissolution rate of Itraconazole tablets. A grouping of Poly ethylene glycol 6000, Poly Vinyl Pyrrolidone and Dicalcium Phosphate was suggested for making Itraconazole tablets with good dissolution characteristics.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.