T786C Polymorphisms of Endothelial Nitric Oxide Synthase 3 (eNOS3) in bas-ketball players

  • Sarab Hussain Khaleel Department of Anatomy, College of Medicine, University of Al-Qadisiyah, Iraq

Abstract

Genetic factor plays important role in athlete’s performance. This study was aimed at the improve fact that the eNOS3-786 T/C polymorphism is a candidate to explain individual variability in athletic performance. The Endothelial Nitric Oxide synthesis gene variants have been studied. The T786C polymorphism of eNOS gene studied in power and endurance sport. We compared genotypic and allelic frequencies of the NOS3 T786c polymorphism in basketball players with the control group. DNA extracts from 35-men players basketball and 40 healthy men as a control. The T 786C polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The frequency of the T allele was significant for basketball players compared to control group (60% vs. 42.5%, P= 0.334). While genotypes disruption there is no statically significant among basketball player (40% TT,40% TC,20% CC) compared with control (30% TT,25% TC, 45% CC), (p=0.365, 0.167, 0.069 respectively). It was concluded the T allele associated with the status of being an elite basketball players and it has a beneficial effect on performance parameters but it needed further study.

Keywords: Endothelial Nitric Oxide synthase, T786C polymorphism, PCR

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Published
2017-10-20
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How to Cite
Sarab Hussain Khaleel. (2017). T786C Polymorphisms of Endothelial Nitric Oxide Synthase 3 (eNOS3) in bas-ketball players. International Journal of Research in Pharmaceutical Sciences, 8(4), 616-620. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/753
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Original Articles
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