Tumor suppressing potential of Cajanus cajan in 7,12-dimethylbenz(a) anthra-cene (DMBA)-induced hamster buccal pouch carcinogenesis

  • Kuselar Hemalatha Research and Development Centre, Bharathiar University, Coimbatore, India
  • Shanmugam Manoharan Department of Biochemistry & Biotechnology, Annamalai University, Annamalainagar, India
  • Musthafa Shabana Begum Department of Biochemistry, Muthayammal College of Arts and Science, Rasipuram, India
  • Mani Neelakandan Department of Biochemistry & Biotechnology, Annamalai University, Annamalainagar, India

Abstract

Traditional medicine has explored the diverse pharmacological efficacy of Cajanus cajan leaves including anti-inflammatory and antioxidant potential. To scientifically validate the tumor inhibitory potential of Cajanus cajan leaves, the present study utilized the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis as an experimental oral cancer model. The ethanolic extract of Cajanus cajan leaves (CcELet) suppressed the tumor formation in the pre- initiation phase and reduced the formation of tumors and tumor size as well in the post-initiation phase. Also, the Cajanus cajan leaves modulated the status of lipid peroxidation, antioxidants, and phase I and phase II detoxification agents towards tumor inhibition in the hamsters treated with DMBA. The results of the study thus explore the anti-tumor potential of Cajanus cajan leaves during DMBA induced hamster buccal pouch carcinogenesis.

Keywords: Cajanus cajan, oral cancer, lipid peroxidation, antioxidants, detoxification agents

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Published
2017-10-20
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How to Cite
Kuselar Hemalatha, Shanmugam Manoharan, Musthafa Shabana Begum, & Mani Neelakandan. (2017). Tumor suppressing potential of Cajanus cajan in 7,12-dimethylbenz(a) anthra-cene (DMBA)-induced hamster buccal pouch carcinogenesis. International Journal of Research in Pharmaceutical Sciences, 8(4), 504-511. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/736
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Original Articles
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