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Abstract

Traditional medicine has explored the diverse pharmacological efficacy of Cajanus cajan leaves including anti-inflammatory and antioxidant potential. To scientifically validate the tumor inhibitory potential of Cajanus cajan leaves, the present study utilized the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis as an experimental oral cancer model. The ethanolic extract of Cajanus cajan leaves (CcELet) suppressed the tumor formation in the pre- initiation phase and reduced the formation of tumors and tumor size as well in the post-initiation phase. Also, the Cajanus cajan leaves modulated the status of lipid peroxidation, antioxidants, and phase I and phase II detoxification agents towards tumor inhibition in the hamsters treated with DMBA. The results of the study thus explore the anti-tumor potential of Cajanus cajan leaves during DMBA induced hamster buccal pouch carcinogenesis.

Keywords

Cajanus cajan oral cancer lipid peroxidation antioxidants detoxification agents

Article Details

How to Cite
Kuselar Hemalatha, Shanmugam Manoharan, Musthafa Shabana Begum, & Mani Neelakandan. (2017). Tumor suppressing potential of Cajanus cajan in 7,12-dimethylbenz(a) anthra-cene (DMBA)-induced hamster buccal pouch carcinogenesis. International Journal of Research in Pharmaceutical Sciences, 8(4), 504-511. Retrieved from https://pharmascope.org/ijrps/article/view/736