Apigenin protects 7, 12-dimethylbenz(a)anthracene–induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters

  • Simon Silvan Department of Biochemistry &Biotechnology, Faculty of Science, Annamalai University, Annamalainagar- 608 002 Tamil Nadu, India
  • Shanmugam Manoharan Department of Biochemistry &Biotechnology, Faculty of Science, Annamalai University, Annamalainagar- 608 002 Tamil Nadu, India
  • Nagarethinam Baskaran Department of Biochemistry &Biotechnology, Faculty of Science, Annamalai University, Annamalainagar- 608 002 Tamil Nadu, India
  • Arjun Kumar Singh Department of Biochemistry &Biotechnology, Faculty of Science, Annamalai University, Annamalainagar- 608 002 Tamil Nadu, India

Abstract

The present study has investigated the protective effect of apigenin on 7, 12-dimethylbenz(a)anthracene (DMBA)-induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters. The protective effect of apigenin was examined by analyzing the frequency of micronucleated polychromatic erythrocytes (MnPCEs), chromosomal aberrations and DNA damage in hamsters treated with DMBA. We noticed an increase in MnPCEs frequency, chromosomal aberrations and DNA damage in hamsters treated with DMBA alone. Oral pretreatment of apigenin for 5 days to DMBA-treated hamsters significantly decreased the frequency of MnPCEs, chromosomal aberrations and DNA damage. The present study thus suggests that apigenin has the ability to prevent 7, 12-dimethylbenz(a)anthracene–induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters.

Keywords: Apigenin, Chromosomal aberrations, DNA damage, DMBA, MnPCEs

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Published
2013-07-15
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How to Cite
Simon Silvan, Shanmugam Manoharan, Nagarethinam Baskaran, & Arjun Kumar Singh. (2013). Apigenin protects 7, 12-dimethylbenz(a)anthracene–induced chromosomal abnormalities and DNA damage in the bone marrow cells of golden Syrian hamsters. International Journal of Research in Pharmaceutical Sciences, 4(3), 445-452. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/683
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Original Articles
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