Lovastatin: history, physicochemistry, pharmacokinetics and enhanced solubility

  • Zolkiflee NF Nanopharmacy Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia
  • Meor Mohd Affandi MMR Pharmaceutical and Life Sciences Core, Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Selangor Darul Ehsan, Malaysia
  • Majeed ABA Pharmaceutical and Life Sciences Core, Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Selangor Darul Ehsan, Malaysia

Abstract

Lovastatin is a statin drug that blocks the body’s synthesis of cholesterol and is administered especially to individuals at risk of heart disease. Categorized as a Biopharmaceutics Classification System (BCS) Class II drugs, lovastatin demonstrates low solubility and bioavailability. This review focuses on the importance of lovastatin and the obstacles during its administration. The history of statins from the discovery until they become one of the successful cholesterol-lowering agents to prevent complications and fatality especially related to coronary heart disease has been outlined along with their recent applicability in neurodegenerative diseases. Due to the respective physicochemical characters of the statins, they pose several challenges related to their effective administration to the patients. The aqueous solubility is the main issue related to their poor bioavailability. Besides that, other solubility and bioavailability enhancement approaches were discussed systemically. Finally, this review suggests current advanced technologies employed in order to provide effective and competent utilization of the drug.

Keywords: Arginine, Lovastatin, Pharmacokinetic, Physicochemistry, Solubility enhancement

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Published
2017-01-10
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How to Cite
Zolkiflee NF, Meor Mohd Affandi MMR, & Majeed ABA. (2017). Lovastatin: history, physicochemistry, pharmacokinetics and enhanced solubility. International Journal of Research in Pharmaceutical Sciences, 8(1), 90-102. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/570
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Original Articles
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