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Abstract

The primary clinical problem of arteriovenous fistula (AVF) is the high maturation failure rate. Curcumin shows anti-inflammatory, antioxidant, antitumorigenic, and antiproliferative effects that may contribute to AVF maturation.  This study investigated the effectiveness of curcumin and acetylsalicylic acid on anti-inflammatory and antitumorigenic effects on AVF maturation in patients with End-Stage Renal Disease (ESRD) with diabetes mellitus (DM).  The present study is a single-blinded, randomized controlled trial consisting of curcumin, acetylsalicylic acid, or placebo intervention for eight weeks. A total of 67 participants completed the intervention. There was a higher level of nitric oxide (NO) between the curcumin and placebo four weeks (92.58±24.70 vs 75.67±16.50 µmol/L, adjusted p = 0.038) and eight weeks (95.27±28.77 vs 76.66±23.24 µmol/L, adjusted p <0.05) postoperatively. Higher-level of NO between acetylsalicylic acid and placebo (93.65±24.65 vs 75.67±16.50 µmol/L, adjusted p = 0.031) four weeks postoperatively. Curcumin increases NO after four and eight weeks and lowers MMP-9 four weeks after AVF operation. Acetylsalicylic acid increases NO four weeks after AVF surgery on ESRD patients with DM.

Keywords

Acetylsalicylic acid Arteriovenous fistula Curcumin Matrix metalloproteinase 9 Nitric oxide

Article Details

How to Cite
Dedy Pratama, Hendro Sudjono Yuwono, Rudi Supriyadi, Herry Herman, Avicenna Akbar, Bany Faris Amin, & Fachreza Aryo Damara. (2021). Curcumin anti-inflammatory and antitumorigenic effect on arteriovenous fistula maturation in patient with end-stage renal disease with diabetes mellitus. International Journal of Research in Pharmaceutical Sciences, 12(3), 2200-2206. https://doi.org/10.26452/ijrps.v12i3.4843