A glance preface and novel approaches for the efficient treatment of a migraine

  • Shefrin S Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India
  • Sreelaxmi CS Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India
  • Sharon Joseph Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India
  • Sreeja C Nair Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, India

Abstract

The reviewing of a migraine mainly aimed to analyze the incessant paroxysmal neurological ailment characterized by moderate to severe head throbbing. The review points out the basic pathophysiology and different types of migraine as well as some of the promising newer antimigraine therapeutic options. The various biomarkers in CSF, as well as blood, are used as standards to diagnose the condition. The triptans released during the 1990s were the initial class of drugs used for acute treatment of migraine. The other conventional therapies offer especially as oral formulations are not exquisitely appropriate for migraineurs having severe nausea and vomiting with reduced gastric absorption. The unmet clinical needs were rapidly advanced, and development of novel drug delivery system ensured better kinetic and dynamic characteristics. The newer drug regimens were more based and targeted on the neurotransmitters directly in involved in the pathophysiology of migraine by utilizing exceptionally confined delivery systems. These include a breath activated the system, transdermal patch, oral inhalers where lower and safer doses of the drug were utilized. Such systems were having improved patient compliance and offered non- invasive route of drug administration that could be suitably substituted by oral medications. The disease disabled the quality of life of patients and also had an abundant effect in the daily activities especially for women. Thus the various nanotechnical approaches are used as novel treatment methods for better and enhanced profiling of drug molecules.

Keywords: A migraine, Trigeminovascular system, Fluid biomarkers, CNS delivery, Therapeutic design, Novel drug delivery

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Published
2019-01-05
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How to Cite
Shefrin S, Sreelaxmi CS, Sharon Joseph, & Sreeja C Nair. (2019). A glance preface and novel approaches for the efficient treatment of a migraine. International Journal of Research in Pharmaceutical Sciences, 10(1), 282-297. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/48
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Original Articles
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