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Abstract

Coordination complex of Zn(II) with 4-mercaptoaniline(4-MTP or 4-ATP) were synthesized under microwave irradiation. The synthesized complex was characterized by elemental analysis, metal estimation, UV-Visible, conductance measurement, IR, Far-IR & NMR (proton and carbon) spectral studies. The metal complex was found to mononuclear, neutral and colorless in nature which are confirmed by the elemental analysis and molar conductance studies. The geometry for 1:2:2 complex exhibits to be square planar were confirmed by its spectral absorption study. The ligand was coordinated to the metal ion through its ‘N’ or ‘S’ atom and diamagnetic nature of the complex to be confirmed by the IR, Far-IR and NMR spectral studies. The electrochemical properties of complex shows the well redox properties of them with Zn(II)/Zn(I) couple by predicting the values of anodic and cathodic current. In-vitro antibacterial and antifungal activities of microorganisms viz., S. Aureus, bacillus  and C. Albicance were carried out by Agar disc diffusion method using Amikacin and ketoconazole as standard control and DMSO as solvent control. The metal complex shows enhanced biological activities than the 4-ATP. The CT-DNA cleavage study of 4-ATP and its Zn(II) complex were performed and calculated the IC50 values. The results show the antioxidant property of 4-ATP and its complex.

Keywords

4-ATP Benzoate ion bio-potential antibacterial antifungal DNA-Cleavage

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How to Cite
Sudhakar P, Rajasekar K, Balasubramaniyan S, Selvarani R, Veeravel C, & Narasimhavarman S. (2021). In-Vitro CT-DNA Cleavage of Newly Synthesized Zn(II) Complex with P-Mercaptoaniline and Benzoate Ion. International Journal of Research in Pharmaceutical Sciences, 12(3), 1950-1955. https://doi.org/10.26452/ijrps.v12i3.4798