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Maternal 25 dihydroxycholecalciferol is the storage form the vitamin D. It gets activated to 1,25, Dihydroxycholecalciferol (vitamin D3) in the kidneys. Pregnancy increases requirement for the vitamin D3. The 1,25 dihydroxycholecalciferol is produced by the fetal kidneys from maternal sources of 25 dihydroxycholecalciferol. Vitamin D3 is essential for intestinal calcium absorption and bone mineralization in fetus.104 venous blood samples were used to study 25 hydroxycholecalciferol and serum calcium levels. Experimental group involved venous blood samples from 100 ANC between 20-40 years. In the first trimester rural ANC cases had an average 25 hydroxycholecalciferol level of 50.9ng/ml. In Urban participants the average was 31.6nmol/L. Second Trimester ANC in rural sector had an average of 54nmol/L and in urban average was 45nmol/L. In third trimester rural participants had an average of 61nmol/L, urban participants had 28nmol/L. The urban participants in all the three trimesters had 25 hydroxycholecalciferol insufficiency. 25 hydroxycholecalciferol deficiency is higher percentage in first trimester, gradually reduces in second trimester and reaches towards normal limits in third trimester. The placental secretion compensates for the homeostasis and maintenance of normal calcium levels and during third trimester. Active fetal bone mineralization occurs in third trimester.
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