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In this current protocol, the antioxidant and antihyperlipidemic activity of Polyherbal formulation (PH) in streptozotocin (STZ)-induced diabetic rats were studied. STZ-induced diabetic rats had near about 50% higher serum cholesterol and 53.06 % higher serum triglyceride levels as compared to non-diabetic rats. Also, a significant increase in SGOT, SGPT and serum creatinine levels (65.02%, 69.11%, 53.05% respectively) were observed in STZ-induced diabetic rats. Quotidian therapy of diabetic group with standard & Polyherbal formulation (200 & 400 mg/kg) for four weeks significantly lowered (P< 0.01) serum cholesterol, triglyceride, hepatic enzymes and serum creatinine levels. Significant improvement in antioxidant activity with Glibenclamide & Polyherbal formulation (200 & 400 mg/kg) treated group were observed as a decrease in MDA level and increase in superoxide dismutase (SOD) and glutathione (GSH) levels. The treatment groups partially reversed the hindrance towards glucose utilizing system and oxidation status in diabetic rats. The study with PH (400 mg/kg) dose has shown marked improvement in histological condition, as compared to the diabetic control. The above results propose that this Polyherbal formulation may be a potential source for the development of the new antidiabetic drug.
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