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Lercanidipine is an antihypertensive drug. It is a dihydropyridine class of calcium channel blockers. It is extremely bitter. The reason for this exploration was to build up a non-bitter orally breaking down the tablet of inadequately solvent medication viz Lercanidipine. The bitterness of drug, masked through complexing Tulsion 339 in various ratios. Sodium starch glycolate, crospovidone, low substituted hydroxypropyl cellulose selected as super disintegrants in the formulation. The formulated tablets were assessed for various properties like Drug content, crushing strength, friability, wetting time, water retention proportion, breaking downtime and in-vitro disintegration time and dissolution studies. The disintegration time obtained in the range between 38.46-51.40 seconds. Release studies observed between 5 to 30 minutes. From the prepared formulations, formulation using Low substituted hydroxypropyl cellulose with 5% concentration showed 98.89% drug release within 30minutes. Thus F9 was considered as best among the other formulations With effective dissolution and improves patient intake. Drug release Kinetic analysis (r2) based on best curve fitting method for optimized lercandipine formulation showed first order kinetics proves that the drug release depends upon its concentration.
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