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Central pontine myelinolysis is an acquired demyelinating condition which is now termed as osmotic demyelination syndrome (ODS) due to associated extra pontine involvement. Although various causes of ODShave been established, rapid correction of hyponatremia remains the commonest. ODS usually presents a decrease in the level of sensorium associated with acute flaccid quadriparesis. The present reported case of 62 year old diabetic male who presented with ataxia, dysarthria and bulbar weakness. His blood sugars and serum osmolality was high. Imaging studies showed hyperintensities in pontine parenchyma suggestive of myelinolysis. The patient recovered symptomatically after correction of hyperglycemia.


Osmotic demyelination syndrome (ODS) Central pontine mye-linolysis (CPM) Hyperglycemic hyper-osmolar state (HHS)

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Mahendra Kumar K, Nithyananthan P, Balaji T, Prasanna Karthik S, Kannan R, & Rajendran K. (2018). A case of hyperglycemia induced osmotic demyelination syndrome. International Journal of Research in Pharmaceutical Sciences, 9(4), 1262-1264. Retrieved from