Absorption enhancement effect of piperine and chitosan on ganciclovir sol-id lipid nanoparticles: formulation, optimization and invivo pharmacoki-netics

  • Ravindra Babu M Research Scholar, Jawaharlal Nehru Technological University Anantapur (JNTUA), Ananthapuramu, Andhra Pradesh -515002, India
  • Ravi Prakash P Creative Educational Society’s College of Pharmacy, Kurnool, Andhra Pradesh, India
  • Devanna N Oil Technological and Pharmaceutical Research Institute, Jawaharlal Nehru Technological University Anantapur (JNTUA), Ananthapuramu, Andhra Pradesh, India

Abstract

The purpose of the present study was to formulate Solid Lipid Nanoparticles (SLNs) of Ganciclovir (GCV) in combination with Chitosan and Piperine for absorption enhancement effect. GCV loaded SLNs were prepared by hot homogenization method, optimized and characterized. Formulated SLNs were incorporated with absorption enhancers and characterized for invitro absorption (with chicken intestine), histopathological and invivo pharmacokinetic studies. Invitro absorption studies revealed that the permeability coefficient of the prepared formulation is more when compared to the pure drug, so the permeability is more for prepared formulation. In vivo pharmacokinetic study showed a significant increase in the Cmax, AUC, biological half-life and decrease in elimination rate constant for prepared formulation compared to pure drug. Histopathological studies also showed mild reversible damage of epithelial cells with Chitosan which indicates the safety and efficacy of the formulation. Thus, GCV loaded SLNs prepared with Chitosan can be clinically promising for enhancing the oral, intestinal absorption of the said BCS Class-III drug.

Keywords: Absorption studies, Everted sac method, Ganciclovir, Invitro absorption stud-ies, Solid Lipid Nanoparti-cles

Downloads

Download data is not yet available.
Published
2019-04-14
Citations
How to Cite
Ravindra Babu M, Ravi Prakash P, & Devanna N. (2019). Absorption enhancement effect of piperine and chitosan on ganciclovir sol-id lipid nanoparticles: formulation, optimization and invivo pharmacoki-netics. International Journal of Research in Pharmaceutical Sciences, 10(2), 1143-1151. https://doi.org/10.26452/ijrps.v10i2.395
Section
Original Articles
Article Level Metrix
Abstract Views: 141
PDF Downloaded: 57