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Abstract

Cancer kills millions of people worldwide every year. The main form of treatment at this point is chemotherapy, which comprises of systemic drug delivery so that they can kill the cancerous cells more effectively. But most of these drugs cause severe side effects in patients and, therefore there is a strong need to focus on identifying natural compounds as a potent phytoinhibitors using various in silico and in vitro approaches. Natural compounds pose low toxicity, hence render them to be an excellent alternative to the basis for the development of new anti-cancerous drugs. Our study considers an effective therapeutic target, Jab1 (c-Jun activation domain-binding protein-1) or a c-Jun coactivator, which has been implicated in multiple protein interactions that play a significant role in various stages of carcinogenesis. Hence we have performed screening of 1500 natural compounds having anticancerous activity by applying various in silico approaches including Lipinski rule of five, ADME, and various Molecular Docking tools. In this study, we have identified two potent phytoinhibitors against Jab1 which needs to be further validated through in vitro approaches.

Keywords

Cancer Signal transduction pathways Natural Compounds Jab1 in silico Chemotherapy Chemopreventive com-pounds

Article Details

How to Cite
Fahad Khan, Pratibha Pandey, Rashmi Mishra, Niraj Kumar Jha, & Shweta Sharma. (2019). An in silico study on plant-derived inhibitors against a prognostic Biomarker, Jab1. International Journal of Research in Pharmaceutical Sciences, 10(2), 1058-1061. https://doi.org/10.26452/ijrps.v10i2.382