Docking, Screening, Synthesis of 4-hydroxy-6-methyl-2-phenyl-1-benzofuran-3(2H)-one derivatives as new leads for anti-cancer activity

  • Raghava Doonaboyina Department of Pharmaceutical Chemistry, Institute of Pharmacy, NIMS University, Jaipur Rajasthan, India
  • Abhilasha Mittal Department of Pharmaceutical Chemistry, Institute of Pharmacy, NIMS University, Jaipur Rajasthan, India
  • Sridhar Babu Gummadi Department of Pharmaceutical Chemistry, Institute of Pharmacy, NIMS University, Jaipur Rajasthan, India

Abstract

Auroneis a bicyclic ring where a benzene ring fused with a furanone. Docking is an efficient tool in the development of new lead molecules. Docking, virtual screening, ADMET prediction are prominent devices in the identification of new lead molecules. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Benzofuranone was synthesized by reacting benzene diols, and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclised with sodium acetate. The compounds identity and purity were confirmed by spectral and analytical methods. Benzofuranone derivatives are screened antineoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compound IIIA was found to be with potent activity.

Keywords: Docking, Virtual Screening, ADMET, Anti-cancer activity, G361 cell line

Downloads

Download data is not yet available.
Published
2019-04-15
Citations
How to Cite
Raghava Doonaboyina, Abhilasha Mittal, & Sridhar Babu Gummadi. (2019). Docking, Screening, Synthesis of 4-hydroxy-6-methyl-2-phenyl-1-benzofuran-3(2H)-one derivatives as new leads for anti-cancer activity . International Journal of Research in Pharmaceutical Sciences, 10(2), 883-895. https://doi.org/10.26452/ijrps.v10i2.271
Section
Original Articles
Article Level Metrix
Abstract Views: 58
PDF Downloaded: 22