Identification of anticancer activity of phytoconstituents from mangrove

  • Sheela Devi A Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Chinna Kolambakkam 603308, Tamil Nadu, India
  • Joseph J Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Chinna Kolambakkam 603308, Tamil Nadu, India
  • Bhuvaneshwari V Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Chinna Kolambakkam 603308, Tamil Nadu, India

Abstract

Medicinal plants from the marine ecosystem are a rich source of medicinal plants having a potential for miracle drugs. It is clear from the observation that the local inhabitants of Pichavaram mangrove forest have excellent knowledge about the phytomedicine. Thus they have developed their traditional system of utilizing these mangroves for medicinal purposes. Cancer is the name given to a collection of related and multistep disease. In all types of cancer, a few of the body's cells begin to divide without stopping and spread into the surrounding. It is developed by environmental, physical, chemical, metabolic and genetic factors. In this study, methanol was used to prepare an extract from A. marina leaves and screened for anticancer activity. The phytoconstituents like alkaloids, flavonoids, saponin and tannin present in the extract were quantified, and anticancer activity of the same was identified. Further, the apoptotic cell death effect of methanol extract on the Hela cell line was determined. The flavonoids of A. marina showed higher anti-cancer activity on Hela cells followed by tannin, alkaloids and saponin. The result of the apoptotic cell death effect of A. marina may provide an effective therapeutic strategy against cervical cancer. Finally, it is concluded that the extract of A. marina exhibited anticancer activity.

Keywords: Avicennia marina, Anticancer, Apoptotic cell death, Cervical cancer, Mangrove, MTT assay

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Published
2019-04-15
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How to Cite
Sheela Devi A, Joseph J, & Bhuvaneshwari V. (2019). Identification of anticancer activity of phytoconstituents from mangrove. International Journal of Research in Pharmaceutical Sciences, 10(2), 791-794. https://doi.org/10.26452/ijrps.v10i2.254
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Review Articles
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