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To estimate the incidence of rheumatoid fever in children. To investigate the clinical finding of Sydenham's chorea in children diagnosed with rheumatoid fever. To measure the efficacy of sodium valproate and carbamazepine from the therapeutic outcomes. To measure the incidence of adverse effects in children administered with sodium valproate and carbamazepine. The present study is a prospective study designed to compare the therapeutic outcomes and side effects of chorea groups administered with sodium valproate and carbamazepine. The study was conducted in Chittoor Government hospital, Chittoor, Andhra Pradesh. The present study was conducted in Chittoor Government Hospital, Chittoor, Andhra Pradesh. The study is a prospective design was conducted in the departments of paediatrics of respective tertiary care hospital which included the patients admitted to children's ward with provisional/ final diagnostic rheumatoid fever. The study conducted after getting the informed consent forms from all the patients included in the study. The patients recruited into the study were divided into 2 chorea groups, and each group were administered with one different drug. From the study, it was concluded that the rate of incidence of rheumatoid fever was relatively decreased from years. However, the initial dose of both the drugs should be tapered slowly for minimizing the dose-related side effects especially like aggressive reaction, weight gain, somnolence and insomnia.