Hypolipidemic and antioxidant potential of hydroalcholic leaf extract of Talinum Portulacifolium against Triton WR-1339 induced dyslipidemia in experimental animals

  • Prasanthi K Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visva Vidyalayam, Tirupati, Andhra Pradesh, India
  • Indira Muzib Y Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visva Vidyalayam, Tirupati, Andhra Pradesh, India
  • Venkateswarlu M Department of Pharmacology, Sri Padmavathi School of Pharmacy, Tiruchanoor, Andhra Pradesh, India

Abstract

Talinum portulacifolium which is known as water plant is traditionally used for its various properties and hence in present study hydroalcoholic extract of plant leaves has been screened for its hypolipidemic activity. Hyperlipidemia is a highly prognostic risk factor for atherosclerosis, coronary artery diseases and cerebrovascular diseases. Triton WR-1339, a non ionic surfactant has been widely used to produce acute dyslipidemia in animal models in order to screen hypolipidemic activity of the extract and serum levels of various biochemical parameters such as total cholesterol, triglycerides, LDL, VLDL and HDL cholesterol and atherogenic index were determined. The animals are grouped into normal, Triton treated group, Triton + Standard, Triton + herb extract (200mg/kg) and Triton + herb extract (400mg/kg). The plant extract showed significant hypolipidemic effect by lowering all biochemical parameters and increases HDL cholesterol levels. These biochemical observations are also confirmed by Histopathological examination of liver. The plant extract also showed good antioxidant potential by increasing SOD, CAT, GSH and decreasing lipid peroxidation.

Keywords: Talinum portulacifolium, Hypolipidemic activity, Lipid profile, Atherogenic index, Triton

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Published
2018-04-10
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How to Cite
Prasanthi K, Indira Muzib Y, & Venkateswarlu M. (2018). Hypolipidemic and antioxidant potential of hydroalcholic leaf extract of Talinum Portulacifolium against Triton WR-1339 induced dyslipidemia in experimental animals. International Journal of Research in Pharmaceutical Sciences, 9(2). Retrieved from https://pharmascope.org/index.php/ijrps/article/view/228
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Original Articles
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