Antihyperglycemic effect of Portulaca pilosa Linn. in streptozotocin-induced diabetic rats

  • Arul Balasubramanian Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem-636 008, Tamil Nadu, India
  • Vijayarangan Sivasamy Department of Pharmacology, Trichy SRM Medical College Hospital and Research Centre, Tiruchi-rappalli-621105, Tamil Nadu, India
  • Manivannan Ekambaram Department of Pharmacology, Vinayaka Mission’s Kirupanandha Variyar Medical College and Hospitals, Vinayaka Mission’s Research Foundation (Deemed to be University), Seeragapadi Salem-636 308, Tamil Nadu, India
  • Kothai Ramalingam Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem-636 008, Tamil Nadu, India

Abstract

The antihyperglycemic activity of ethanolic extract of Portulaca pilosaLinn. was evaluated against streptozotocin-induced diabetic rats. The blood glucose levels were calculated at various time intervals of 0, 1, 2 and 3 h after the administration of ethanolic extract of P.pilosa. The ethanolic extract reduced the blood glucose levels significantly when it was administered at three doses of 100, 200 and 400 mg/kg. It reduces the blood glucose level from 334.67±5.27 to 134.57±6.49 at 3h after the administration of 200 mg/kg of ethanolic extract. The antihyperglycemic activity was evaluated in comparison of the administration of an oral hypoglycemic agent, Tolbutamide.

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Published
2019-02-04
How to Cite
BALASUBRAMANIAN, Arul et al. Antihyperglycemic effect of Portulaca pilosa Linn. in streptozotocin-induced diabetic rats. International Journal of Research in Pharmaceutical Sciences, [S.l.], v. 10, n. 1, p. 673-676, feb. 2019. ISSN 0975-7538. Available at: <https://pharmascope.org/index.php/ijrps/article/view/1900>. Date accessed: 22 mar. 2019. doi: https://doi.org/10.26452/ijrps.v10i1.1900.
Section
Original Articles
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