The cellular genetics effect of pyrethroid on lab rabbits

  • Eqbal Dohan Chalap Department of Radiological Techniques, Al-Mustaqbal University College, Babylon, Iraq
  • Farah Safaa Abdulhussein Department of Pathological Analyzes, Al-Mustaqbal University College, Babylon, Iraq
  • Dhuha Salman Asker Aljuboory Department of Pathological Analyzes, Al-Mustaqbal University College, Babylon, Iraq

Abstract

The mutagenicity and genotoxicity of sumicidin insecticide 30 EC, which is classified as a synthetic pyrethroid w 30 studied using mitotic index (MI) and chromosomal aberration (CA) in somatic cells (bone marrow and spleen) and male germ cells of rabbits. Sumicidin was administered orally at dose level (2 X 10-5, 2.5 X 10-5, 3 X 10-5M) and control dose level of mitomycin C. Result show that high doses of sumicidin cause a significant reduction in MI and a significant increase in CA for all tissues. Reduction in MI level was significantly higher (p<0.01) in bone marrow and male germ cells than spleen while there is a significant increase in CA level in male germ cells, compared with somatic cells. These results indicate that sumicidin 30 EC is potentially genotoxic in rabbits.

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Published
2019-02-04
How to Cite
DOHAN CHALAP, Eqbal; SAFAA ABDULHUSSEIN, Farah; ASKER ALJUBOORY, Dhuha Salman. The cellular genetics effect of pyrethroid on lab rabbits. International Journal of Research in Pharmaceutical Sciences, [S.l.], v. 10, n. 1, p. 415-418, feb. 2019. ISSN 0975-7538. Available at: <https://pharmascope.org/index.php/ijrps/article/view/1866>. Date accessed: 20 feb. 2019. doi: https://doi.org/10.26452/ijrps.v10i1.1866.
Section
Original Articles
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