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Abstract

The current investigation was to examine the antioxidant potential of D.littoralis Nees. (family Acanthaceae) On paracetamol-induced hepatotoxicity in rats. The aerial parts of D.littoralis Nees. The powder was concentratesed with various solvents (PE, EA, and methanol) through Soxhlet concentrates and various crude concentrates utilized for hepatoprotective activity.  Hepatotoxicity was induced by paracetamol (2g/kg b.wt.) on the 5th day of the investigational period and given orally.  Paracetamol-induced rats to exhibit elevated activities of TBARS  and reduction the enzymes levels such as Superoxide dismutase(SOD), catalase(CAD), Glutathione peroxidise (GPx), Glutathione S transferase(GST) and Glutathione (GSH) in liver and kidney.  Furthermore, Oral administration of the  ethyl acetate  concentrates of  D.littoralis (200 mg/ kgb.wt.) given  rats were major reduction the level of TBARS and  also significantly elevated the levels of the enzyme such as Superoxide dismutase(SOD), catalase(CAD), Glutathione peroxidise(GPx), Glutathione S transferase(GST) and Glutathione (GSH)  in liver and kidney as compared to other concentrates. Thus, results suggested that ethyl acetate concentrates of D.littoralis could be afford better antioxidant effect against paracetamol-induced hepatotoxicity rats.

Keywords

D.littoralis Paracetamol antioxidant enzyme superoxide dismutase catalase

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How to Cite
Ravi Teja P D, Balakrishnan M, & Kottai Muthu A. (2020). Study on lipid peroxidation and In vivo antioxidant activity of various extract of Dyschoriste littoralis nees on paracetamol-induced hepatotoxicity rats. International Journal of Research in Pharmaceutical Sciences, 11(1), 335-341. https://doi.org/10.26452/ijrps.v11i1.1826