Studies on e-pharmacophore based virtual screening and evaluation of hy-polipidemic activity of leucocynidin in hyperlipidemic induced rats

  • Dhivya Jensi V Department for Advanced Computing and Bioinformatics, PRIST University, Thanjavur-613403, Tamil Nadu, India
  • Ananda Gopu P Department for Advanced Computing and Bioinformatics, PRIST University, Thanjavur-613403, Tamil Nadu, India

Abstract

The present study was designed to analyze energy-optimized structure primarily based pharmacophore virtual screening and high score compound was elect and used for hypolidemic activity in rat fed with high fat diet. supported the e-pharmacophore virtual screening analysis discovered that the one in every of the compound particularly leucocynidin has been elect for the hypolipidemic activities. In treatment of Leucocynidin group of animals fed with HFD was considerably  reduction within the body weight compared to HFD fed cluster of animals. The enlarged the levels of TC,TG, phospholipids, LDL-C and VLDL-C were noticed in  group  2 animals (HFD). when the activity of leucocynidin (15mg per weight unit body weigh per day) showed a major (p<0.001) decrement in plasma and TC,TG, phospholipids, LDL-C and VLDL-C in conjunction with an increment within the High density lipoprotein-C compared with group 2  animals(HFD). Taking under consideration the outcomes, we tend to over that leucocynidin may be a considerably hypolipidemic agent having preventive and curative activity against lipidemia.

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Published
2019-02-02
How to Cite
JENSI V, Dhivya; GOPU P, Ananda. Studies on e-pharmacophore based virtual screening and evaluation of hy-polipidemic activity of leucocynidin in hyperlipidemic induced rats. International Journal of Research in Pharmaceutical Sciences, [S.l.], v. 10, n. 1, p. 196-203, feb. 2019. ISSN 0975-7538. Available at: <https://pharmascope.org/index.php/ijrps/article/view/1799>. Date accessed: 20 feb. 2019. doi: https://doi.org/10.26452/ijrps.v10i1.1799.
Section
Original Articles
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