Assessment of Novel Cardiovascular biomarkers in patients with chronic heart failures

  • Abbas Sabbar Dakhil Department of Physiology, Faculty of Medicine, University of Al-Qadisiyah, 58001, Iraq

Abstract

In a recent analysis, incessant heart failure (HF) stays a significant remedial test with decreased launch division. There is a growing need to tame HF in contemporary. In a bid to the reduction of financial burden and mortality rate brought by chronic heart, failure medics have developed approaches to deal with situations to enhance the better living condition of people. The current study was aimed to the investigation of new cardiovascular biomarkers, for instance, development factor 15 (GDF-15),soluble suppression of tumorigenicity (sST2), heart-type fatty acid-binding protein (H-FABP), and urokinase plasminogen activator receptor (suPAR) in patient with dilative cardiomyopathy (DCM) or ischaemic (ICM).200 patients from different parts were enrolled in the study for analysis of the diseases. The various test was carried out on patients who presented themselves in the lab. As the control measure in the study, they included around 76 patients without heart failure or coronary artery diseases. 59 patients who were suffering from ICM and 65 who were diagnosed with DCM were included in the study. The analysis was conducted through the use of ELISA by taking a sample of samples from all patients.H-FABP, suPAR and sST2 were high in patients with DCM and ICM contrasted with the control gathering (p <0.00010).The analysis also indicated that there was no significant difference between DCM and ICM biomarker levels. Analysis indicates that novel cardiovascular biomarkers, for instance, GDF-15, ST2, H-FABP, and uPAR, offers high potential for diagnostic DCM and ICM patient precisely.

Keywords: Biomarkers, Chronic heart failure, GDF-15, ST2, H-FABP, suPAR

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Published
2019-11-30
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How to Cite
Abbas Sabbar Dakhil. (2019). Assessment of Novel Cardiovascular biomarkers in patients with chronic heart failures. International Journal of Research in Pharmaceutical Sciences, 10(4), 3728-3732. https://doi.org/10.26452/ijrps.v10i4.1761
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Original Articles
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