Evaluation of hydrated extract of phaseolus Vulgaris L. (bean plant) on hypoglycemia and hypolipidemic in streptozotocin-induced diabetic albino Wistar rats

  • Helisha Ruth Obonyo Research Scholar, PG and Research Department of Biochemistry Bharathidasan College of Arts and Science, Erode, Tamil Nadu, India
  • Senthemarai Selvi V Research Department of Biochemistry Bharathidasan college of Arts and Science , Erode, Tamil Nadu, India

Abstract

The current research was intended to comprehend hypoglycemic and anti-lipidaemic exercises of hydrated common bean (phaseolus Vulgaris L.) seed extracts on streptozotocin-induced diabetic albino rats. At a set portion fluctuate of 100, 200,300 mg/kg body weight of common bean extracts was orally directed as one portion for every day to polygenic disorder rats for a measure of thirty days. The impact of P.vulgaris L. on hypoglycemic, glycosylated hemoprotein (HbA1c) and blood serum lipid profile (Total cholesterin), Triglyceride (TG), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), High-density lipoprotein (HDL)) in plasma were estimated in the regular and diabetic induced rat. The outcomes demonstrated that quick glucose,serum TC, TG, LDL, VLDL, levels were significantly (p<0.05) attenuate, while blood serum HDL, the level was extensively (p<0.05) upgraded inside the diabetic rats. The inconclusive amount of pace of 300 mg/kg is more reasonable than that of a hundred mg/kg. Our examination so shows that Phaseolus vulgaris L has a powerful adversary to diabetic and anti-lipidaemic impacts on streptozotocin-induced diabetic rats, and results were comparable to reference drug glibenclamide.

Keywords: Aldohexose, Bean plant, LDL, glibenclamide, Polygenic disorder, STZ, SGPT

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Published
2019-11-29
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How to Cite
Helisha Ruth Obonyo, & Senthemarai Selvi V. (2019). Evaluation of hydrated extract of phaseolus Vulgaris L. (bean plant) on hypoglycemia and hypolipidemic in streptozotocin-induced diabetic albino Wistar rats. International Journal of Research in Pharmaceutical Sciences, 10(4), 3704-3710. https://doi.org/10.26452/ijrps.v10i4.1757
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Original Articles
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