Genotoxic property of poly herbal formulation of annona squomosa, zingiber officinalis and triticum aestivum plant extracts by in vitro chromosomal aberration test

  • Rajesh R Department of Biotechnology, Tumkur University, Tumkur- 572106, Karnataka, India
  • Jagadeesh Singh S D Department of Pharmacognosy and Biotechnology, East Point Research Academy, Bangalore, India
  • Channabasava R Department of Toxicology, Liveon Biolabs Private Limited, Tumakuru, Karnataka, India

Abstract

The present study was aimed to evaluate the genotoxic potential of polyherbal formulations by chromosomal aberration test. Cancer being the second most cause of death among all ailments even after the improvised medications needs alternative sources of treatment. Herbal sources were always among the one as prime treatment sources. Polyherbal formulations were taking the lead in medications because of their broad spectrum of activity and synergic effects. Annona squamosa, Zingiber Officinalis, and Triticum Aestivum formulation with 1:2:3 ratio has shown significant results in the definitive and confirmatory chromosome aberration assays. Indicated the test article PF3 did not induce a statistically significant increase in the percentage of cells with aberrations both in the presence and absence of metabolic activation. PF3 was found non-clostagenic at a maximum dose of 15 µg/ml in the CHO cell line. Inhibition of chromosomal aberration, DNA fragmentation, and maintenance of cellular integrity may prevent the genotoxic effect. Further optimization and in vivo authenticated studies need to be proven.

Keywords: Genotoxicity, Poly herbal, Chromosomal aberration, CHO Cells, Cytotoxicity and Mitotic index

Downloads

Download data is not yet available.
Published
2019-11-05
Citations
How to Cite
Rajesh R, Jagadeesh Singh S D, & Channabasava R. (2019). Genotoxic property of poly herbal formulation of annona squomosa, zingiber officinalis and triticum aestivum plant extracts by in vitro chromosomal aberration test. International Journal of Research in Pharmaceutical Sciences, 10(4), 3449-3460. https://doi.org/10.26452/ijrps.v10i4.1662
Section
Original Articles
Article Level Metrix
Abstract Views: 8
PDF Downloaded: 9           LaTeX Downloaded: 2           HTML Downloaded: 0           ePUB Downloaded: 0