The anti-inflammatory activity of azilsartan in animal models of experimentally-induced chronic and granulomatous inflammations

  • Wael Waleed Mustafa Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq
  • Samer Shukor Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq
  • Saad Abdulrahman Husain Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq
  • Naza Mohammed Ali Mahmood Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Kurdistan Region, Iraq

Abstract

It is well documented that blockade of angiotensin II type 1 receptor may interfere with the progression of the inflammatory processes. The present study aims to evaluate the dose-response relationship of the anti-inflammatory activity of azilsartan in rat models of chronic and granulomatous inflammation. The study includes two parts: First part: 42 rats were allocated into 7 groups, each containing six rats, to evaluate the anti-inflammatory activity of different doses of azilsartan in the rat model of formalin-induced chronic inflammation. Second part: 42 rats were allocated as in 1st group to evaluate the anti-inflammatory activity of azilsartan in the rat model of cotton pellet-induced granuloma. Azilsartan in a dose-dependent pattern (0.125, 0.25, 0.5, 1.0 and 2.0 mg/kg), significantly attenuated inflammation in both rat models utilized in the study with maximum effect achieved with 1.0 mg/kg, which is comparable to that reported for dexamethasone and relative linearity within the lowest dose range. In conclusion, azilsartan decreased formalin-induced chronic inflammation and cotton-pellet induced granuloma in rats in a dose-dependent pattern. Therefore, it may be considered as a potential candidate for treating chronic inflammatory conditions in human.

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Published
2018-10-31
How to Cite
WALEED MUSTAFA, Wael et al. The anti-inflammatory activity of azilsartan in animal models of experimentally-induced chronic and granulomatous inflammations. International Journal of Research in Pharmaceutical Sciences, [S.l.], v. 9, n. 4, p. 1162-1168, oct. 2018. ISSN 0975-7538. Available at: <https://pharmascope.org/index.php/ijrps/article/view/1649>. Date accessed: 13 dec. 2018. doi: https://doi.org/10.26452/ijrps.v9i4.1649.
Section
Original Articles
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