Comparative evaluation of wound healing activity of tilvadi ghrita and durva ghrita on diabetic wound model in rats

  • Shakila Shabbeer Shaikh Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- Pune, Maharashtra, India
  • Krishna Murthy Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- Pune, Maharashtra, India
  • Rajkumar V. Shete Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- Pune, Maharashtra, India
  • Rahul S. Solunke Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor- Pune, Maharashtra, India

Abstract

Previous studies proved the wound healing potential of Tilvadi Ghrita (TG) and Durva Ghrita (DG) on normal wounds, so this study was conducted to investigate wound healing activity of TG and DG on diabetic wound model in rats. Forty-eight adult female Wistar rats in eight groups were used. Alloxan was used to induce diabetes in diabetic groups. Excision wound was made on the dorsal shaved surface of rats, and then Framycetin sulfate cream (FSC) 10%, TG and DG were applied in control and treatment groups. While in normal control and diabetic control groups, no medication was done. Wound photographs were taken on alternative days to evaluate wound healing. Percentage wound contraction, the effect on wound size, and epithelization period parameters were studied. Ghritas were investigated for their preliminary phytochemicals, Physico-chemical properties, skin irritation test, and wound healing activity in normal and diabetic rats. Data were expressed as mean ± SEM and analyzed using Two-way ANOVA followed by Bonferroni’s multiple range test. Studies revealed that TG and DG do not cause any harmful skin reactions, so both ghritas were found to be safe for topical application. Both formulations showed better and fast healing as compared to untreated normal and diabetic control groups. After comparative investigation, it was observed that DG possesses higher wound healing potential in normal and diabetic groups with comparison to TG. Wound healing action in normal and diabetic wounds, it endowed due to the presence of different phytoconstituents reported in the literature and proved to be beneficial in the management of wounds.

Keywords: Diabetic wound, Durva Ghrita, Excision wound model, Tilvadi Ghrita, Wound healing

Downloads

Download data is not yet available.
Published
2019-10-16
Citations
How to Cite
Shakila Shabbeer Shaikh, Krishna Murthy, Rajkumar V. Shete, & Rahul S. Solunke. (2019). Comparative evaluation of wound healing activity of tilvadi ghrita and durva ghrita on diabetic wound model in rats. International Journal of Research in Pharmaceutical Sciences, 10(4), 3376-3384. https://doi.org/10.26452/ijrps.v10i4.1647
Section
Original Articles
Article Level Metrix
Abstract Views: 22
PDF Downloaded: 23           LaTeX Downloaded: 7           HTML Downloaded: 7           ePUB Downloaded: 2