Evaluation of the hepatoprotective and antioxidant activity of ethanolic extract of Nerium indicum Mill. leaves against carbon tetrachloride-induced hepatotoxicity in albino rats

  • Chakali Ayyanna Department of Pharmacology, CES College of pharmacy, Kurnool, Andhra Pradesh, India
  • Tahseen Banu D Department of Pharmacology, CES College of pharmacy, Kurnool, Andhra Pradesh, India
  • Rafiq Hussain G Department of Pharmacology, CES College of pharmacy, Kurnool, Andhra Pradesh, India
  • Sudha Rani D Department of Pharmacology, CES College of pharmacy, Kurnool, Andhra Pradesh, India
  • Madhan Mohan G Department of Pharmacology, CES College of pharmacy, Kurnool, Andhra Pradesh, India
  • Shahanaz Khatoon B Department of Pharmacology, CES College of pharmacy, Kurnool, Andhra Pradesh, India
  • Sneha Reddy B Department of Pharmacology, CES College of pharmacy, Kurnool, Andhra Pradesh, India

Abstract

To investigate the hepatoprotective and antioxidant activity of ethanolic extract of Nerium indicum leaves (EENIL) against CCl4 induced hepatotoxicity in Albino rats. Two groups of 6 rats each were administered with EENIL at the doses of 200 and 400 mg/kg (p.o) for 7 days respectively and at day 7, hepatotoxicity was induced in the rats of all groups with 1.25 ml/kg (i.p) dose of CCl4. The effects of EENIL on antioxidant activity, SGOT, SGPT, ALP and direct bilirubin were determined and histopathological examination of the liver sections was also carried out. The extract prevented the depletion of GSH and CAT levels and also prevented the increment of LPO levels against CCl4 induced liver injury in rats. It also significantly reduced the levels of biochemical liver enzymes with maximum hepatoprotection at 200 mg/kg dose level which was supported by the histopathological observations. The results of the present study strongly reveal that EENIL has hepatoprotective and antioxidant activity against CCl4 induced hepatic damage in experimental animals.

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Published
2018-10-30
How to Cite
AYYANNA, Chakali et al. Evaluation of the hepatoprotective and antioxidant activity of ethanolic extract of Nerium indicum Mill. leaves against carbon tetrachloride-induced hepatotoxicity in albino rats. International Journal of Research in Pharmaceutical Sciences, [S.l.], v. 9, n. 4, p. 1088-1095, oct. 2018. ISSN 0975-7538. Available at: <https://pharmascope.org/index.php/ijrps/article/view/1636>. Date accessed: 12 dec. 2018. doi: https://doi.org/10.26452/ijrps.v9i4.1636.
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Original Articles
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