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Diabetes is one of the growing health crises. The current study was conducted to analyze the impact of glycaemia, dyslipidemia and anxiety level on oxidative stress in prediabetic and diabetic subjects. This cross-sectional study comprised of 140 subjects. Based on ADA criteria, subjects were divided into diabetic patients (n= 54) and pre-diabetic patients (n=44). Forty-two healthy subjects with normal fasting blood glucose level were served as a control group. Anthropometric measurements and blood pressures were measured using standard procedures. The biochemical parameters for measuring oxidative stress, blood glucose levels and lipid profile were estimated. Anxiety level was measured using the STAI questionnaire. The serum malondialdehyde (MDA) levels (nmol /ml) were significantly higher in pre-diabetes (3.14±0.42) and diabetes mellitus (3.43±0.78) compared to normal controls (2.26±1.08). The superoxide dismutase (SOD) activity (U/ml) were higher in diabetes (11.35±3.51) and pre-diabetic subjects (8.55±2.50) compared to healthy subjects (8.11±4.11). MDA had a significant positive correlation with Fasting blood sugar (FBS), Glycosylated hemoglobin (HbA1c), waist to hip ratio and waist circumference. SOD also had a significant correlation with FBS, HbA1c, waist circumference, waist to hip ratio and Body Mass Index. The present study confirmed that diabetic and prediabetic patients are suffered from more oxidative stress than nondiabetic subjects, and it is influenced by their glycemic status and abdominal obesity which is leading to the progression of the disease. Dyslipidemia and anxiety levels didn't mark influence on oxidative stress in prediabetic and diabetic patients.
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