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The aim of the study was to test the anti-bacterial, and anti-fungal activity of four medical plants extract the A.arabica, T.chebula, A.indica, and V.vinifera against the streptococcus mutants and Candida albicans organisms. The extracts obtained from the medicinal plant of A.arabica, T.chebula, A.indica, and V.vinifera was procured and powdered. The minimum inhibitory concentration of the obtained extracts was determined by using the tube dilution method, and the bacterial strains of Streptococcus mutants and Candida albicans were cultured into the extract obtained at a concentration of 1mg/ml, 500µg/ml, 250µg/ml, and 100µg/ml respectively. The extracts obtained from A.arabica and T.chebula had a better anti-bacterial property when compared to the other two medicinal plants and the extracts obtained from A.indica and V.vinifera had a better anti-fungal property when compared to the other two medicinal plants. These plants extracts showed the anti-bacterial property in previous studies to add on to the review of literature in our study it proved that A.indica and V.vinifera had a better anti-fungal activity when compared to another two medicinal plant extract. The clinical significance of the medicinal plant extract can be effectively used as an anti-bacterial and anti-fungal agent as it was compared with the gold standard values of Streptomycin and Amphotericin B.
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