Quinazolinone novel derivatives synthesis and their Biological Evaluation as Antimicrobial and Antitubercular agents

  • Neha Krishnarth Dr. K. N Modi Institute of Pharmaceutical Education and Research, Old Cloth Mill Compound, Opp. S .B. I Main Branch, Modinagar-201201, India
  • Santosh Kumar Verma Faculty of Pharmaceutical Sciences, Motherhood University, Vill. Karoundi, Dehradun Road, P.O. Bhagwanpur, Roorkee, Distt. Haridwar (Uttrakhand)-247661, India
  • Anurag Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Baghpat Crossing, NH-58, Bypass Road, Meerut-250005, India

Abstract

At a global level, tuberculosis (TB) is the disease of human values. It suffers from major health, social and economic burden in many countries. There is an inability of an effective vaccine or the use of vaccine were too long and expensive, have increased risk of spread of this disease.  A  series of quinazolinone derivatives prepared with the help of 2-Amino-3,4,5-trimethoxy benzoic acid and Vilsmeir reagent.  Synthesized  compounds  were  characterized  by  various  spectral  methods.  Different activity like antimicrobial activity of the synthesised compounds were performed,  and the most active compounds of the series were further screened for antitubercular activity against bacteria mycobacterium  H37Rv.  Results  showed that all the synthesized compounds have antimicrobial activity. Compounds  IV c,  IV f, IV h  and IV o showed maximum activity in the synthesized series.  These four compounds further screened for antitubercular activity.  Compounds  IV c,  IV f, IV h  and  IV o showed significant antitubercular activity.

Keywords: Quinazolinone, Vilsmeir reagent, Mycobacterium H37Rv, antitubercular, antimicrobial

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Published
2019-10-16
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How to Cite
Neha Krishnarth, Santosh Kumar Verma, & Anurag. (2019). Quinazolinone novel derivatives synthesis and their Biological Evaluation as Antimicrobial and Antitubercular agents. International Journal of Research in Pharmaceutical Sciences, 10(4), 3026-3034. https://doi.org/10.26452/ijrps.v10i4.1590
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Original Articles
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