Better in solubility enhancement : salt or cocrystal?

  • Iyan Sopyan Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia
  • Tazyinul Qoriah Alfauziah Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia
  • Dolih Gozali Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia

Abstract

Nowadays, most of marketed APIs are in the salt form. But not every single API was ionizable. Thus cocrystallization technique arised to overcome the problem. The aim of this review is to compare the solubility profile of salt and cocrystal. Both salt or cocrystal were used to improve the solubility of APIs and claimed for each other, which is the most effective in solubility enhancement. The salt was formed by ionic interaction, whilst cocrystal formed by hydrogen. Both interactions changed the interaction energy and crystal packing, thus changing the physicochemical properties of APIs. Besides, other factors affecting the solubility of the binary system were melting point, particle morphology, and solubility of coformer. The solubility comparison led to understand the underlying mechanism on solubility enhancement of salt and cocrystal itself.

Keywords: salt, cocrystal, solubility, crystal engineering

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Published
2019-10-16
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How to Cite
Iyan Sopyan, Tazyinul Qoriah Alfauziah, & Dolih Gozali. (2019). Better in solubility enhancement : salt or cocrystal?. International Journal of Research in Pharmaceutical Sciences, 10(4), 3013-3025. https://doi.org/10.26452/ijrps.v10i4.1589
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Original Articles
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