Estimation of Valsartan and Nebivolol in pharmaceutical dosage forms by absorption ratio method
A new Absorption Ratio method was developed and validated for the determination of Valsartan and Nebivolol in tablets. Calibration curves for Valsartan and nebivolol over concentration range of 4 - 80 µg/ml were plotted and molar absorptivity for both the drugs were calculated at both the wavelengths of 281 nm (l-max of nebivolol) and 276.5 nm (iso- absorptive point). The results of analysis have been validated statistically and by recovery studies. The value of standard deviation was satisfactory and recovery studies ranging from 98.74-101.27 % for Valsartan and 98.06-102.96% for nebivolol were indicative of the accuracy and precision of the proposed method. The results of the assay are in good agreement with the label amount. The method was found to be simple, rapid, and accurate and can be adopted in routine analysis of these drugs in formulations. Due to these attributes, the proposed method could be used for routine analysis of these drugs in combined dosage forms.
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