Key conditions of alpha-tocopherol encapsulation in gum Arabic dispersions

  • Muhammad Fuad Al Khafiz Postgraduate Chemistry Program, Faculty of Science and Mathematics, Diponegoro University - Jl. Prof. Soedarto, SH 50 275 , Semarang, Indonesia
  • Yuanita Hikmahwati Chemistry Program, Faculty of Science and Mathematics, Diponegoro University - Jl. Prof. Soedarto, SH 50 275 , Semarang, Indonesia
  • Khairul Anam Chemistry Department, Faculty of Science and Mathematics, Diponegoro University - Jl. Prof. Soedarto, SH 50 275 , Semarang, Indonesia
  • Dwi Hudiyanti Chemistry Department, Faculty of Science and Mathematics, Diponegoro University - Jl. Prof. Soedarto, SH 50 275 , Semarang, Indonesia

Abstract

Alpha-tocopherol or TOC is among substances that has medicinal capabilities. However, alpha-tocopherol is vulnerable to surrounding milieu settings. This leads to the necessity to shield it against unforeseen alterations during the storing or handling procedures. Encapsulation is presented as a procedure which can shield active agents from adverse changes by means of coating with polymers. In this study, gum Arabic (GA), a biopolymer derived from Acacia species, was used as the encapsulation matrix. Encapsulation process was done at different concentrations of GA dispersions (10%, 20%, 30% and 40%) and at various pH levels (5.4, 6.4, 7.4 and 8.4). To evaluate the key conditions of TOC encapsulation in GA dispersion we analysed TOC encapsulation efficiency (EE) and rate of release (RR) from GA dispersions as well as loading capacity (LC) of GA for TOC. The EE, RR and LC were determined by measuring the TOC concentration in the GA dispersions using UV Visible spectrophotometry at 291 nm. Results disclosed that the key conditions for achieving a high LC by GA with high efficiency of TOC encapsulation were in a dispersion of 20% GA at pH range of 6.4 and 7.4. The best EE of TOC and LC of GA were 48% and 2.8%, respectively, with a TOC average RR of 1.05-1.09 ppm/day. The results indicate that gum Arabic is a potential matrix to encapsulate alpha-tocopherol.

Keywords: Drug delivery system, Encapsulation efficiency, Loading capacity, Rate of release

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Published
2019-10-16
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How to Cite
Muhammad Fuad Al Khafiz, Yuanita Hikmahwati, Khairul Anam, & Dwi Hudiyanti. (2019). Key conditions of alpha-tocopherol encapsulation in gum Arabic dispersions. International Journal of Research in Pharmaceutical Sciences, 10(4), 2622-2627. https://doi.org/10.26452/ijrps.v10i4.1520
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Original Articles
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